核受體靶點(diǎn)篩選

?目前發(fā)現(xiàn)48個(gè)成員，與代謝性疾病關(guān)系密切

?建立了以熒光素酶報(bào)告基因?yàn)橹鞯暮耸荏w篩選平臺

已建立的核受體列表

Nuclearreceptorfamily

Targets

Thyroid hormone receptor

TRα, TRβ

Peroxisome proliferator-activated receptor

LXRα, LXRβ, FXR, FXR-β

Retinoic acid receptor

RARα, RARβ, RARγ

Liver X receptor-like

LXRα,LXRβ

3-Ketosteroid receptors

GR,MR, PR, AR

Estrogen receptor

Erα, Erβ

Example：熒光素酶報(bào)告基因驗(yàn)證